Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila
Identifieur interne : 000245 ( Main/Exploration ); précédent : 000244; suivant : 000246Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila
Auteurs : Sergey A. Sinenko [États-Unis] ; Jiwon Shim [États-Unis] ; Utpal Banerjee [États-Unis]Source :
- EMBO reports [ 1469-221X ] ; 2012-01.
English descriptors
- Teeft :
- Antp, Banerjee, Biology organization, Cortical zone, Crystal cells, Drosophila, Egfr, Embo, Embo reports, Error bars, Finkel, Finkel holbrook, Foxo, Gal4, Haematopoietic, Haematopoietic niche, Haemocytes, High levels, Immune, Immune challenge, Immune response, Immunity sinenko, Inactivation, Infestation, Lamellocyte, Lamellocyte differentiation, Lamellocyte numbers, Lamellocyte response, Lamellocytes, Large numbers, Larva, Lymph, Lymph gland, Melanotic capsules, Niche, Normal growth conditions, Online, Oxidative, Oxidative status, Oxidative stress, Pathway, Progenitor, Progenitor cells, Reactive, Reactive oxygen species, Receptor, Scientific report, Significant effect, Significant increase, Sinenko, Single copy, Sod2, Spitz, Standard deviation, Wasp, Wasp eggs, Wasp infestation.
Abstract
Oxidative stress induced by high levels of reactive oxygen species (ROS) is associated with the development of different pathological conditions, including cancers and autoimmune diseases. We analysed whether oxidatively challenged tissue can have systemic effects on the development of cellular immune responses using Drosophila as a model system. Indeed, the haematopoietic niche that normally maintains blood progenitors can sense oxidative stress and regulate the cellular immune response. Pathogen infection induces ROS in the niche cells, resulting in the secretion of an epidermal growth factor‐like cytokine signal that leads to the differentiation of specialized cells involved in innate immune responses.
The haematopoietic niche is shown to sense localized oxidative challenge induced by pathogen infection, and respond by eliciting a systemic effect on immune function, leading to innate immune cell differentiation.
Url:
DOI: 10.1038/embor.2011.223
Affiliations:
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species (ROS) is associated with the development of different pathological conditions, including cancers and autoimmune diseases. We analysed whether oxidatively challenged tissue can have systemic effects on the development of cellular immune responses using Drosophila as a model system. Indeed, the haematopoietic niche that normally maintains blood progenitors can sense oxidative stress and regulate the cellular immune response. Pathogen infection induces ROS in the niche cells, resulting in the secretion of an epidermal growth factor‐like cytokine signal that leads to the differentiation of specialized cells involved in innate immune responses.</div><div type="abstract">The haematopoietic niche is shown to sense localized oxidative challenge induced by pathogen infection, and respond by eliciting a systemic effect on immune function, leading to innate immune cell differentiation.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Los Angeles</li></settlement></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Sinenko, Sergey A" sort="Sinenko, Sergey A" uniqKey="Sinenko S" first="Sergey A" last="Sinenko">Sergey A. Sinenko</name></region><name sortKey="Banerjee, Utpal" sort="Banerjee, Utpal" uniqKey="Banerjee U" first="Utpal" last="Banerjee">Utpal Banerjee</name><name sortKey="Banerjee, Utpal" sort="Banerjee, Utpal" uniqKey="Banerjee U" first="Utpal" last="Banerjee">Utpal Banerjee</name><name sortKey="Banerjee, Utpal" sort="Banerjee, Utpal" uniqKey="Banerjee U" first="Utpal" last="Banerjee">Utpal Banerjee</name><name sortKey="Shim, Jiwon" sort="Shim, Jiwon" uniqKey="Shim J" first="Jiwon" last="Shim">Jiwon Shim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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